Effects of biologic therapy for chronic rhinosinusitis with nasal polyps on airflow and nasal resistance : preliminary results = Efectos de la terapia biológica sobre el flujo aéreo y la resistencia nasal en pacientes con rinosinusitis crónica con pólipos : resultados preliminares

Abstract

Trabajo fin de Máster de Formación Permanente en Rinología Avanzada y Base de Cráneo Anterior (2022-23). Tutor: Dr. D. Juan Maza Solano. Main objective: to assess the effect of monoclonal antibodies on nasal airflow in patients with chronic rhinosinusitis with nasal polyposis, with or without associated endoscopic sinus surgery during treatment. Design: Prospective cohort study. Setting: secondary care hospital. Participants: patients suffering from severe chronic rhinosinusitis with nasal polyps and comorbid severe asthma staring treatment with a monoclonal antibody. Outcomes measure: active anterior rhinometry was performed at baseline, and during treatment at weeks 16, 24 and 52. Also, after endoscopic sinus surgery, if performed. Conclusions: a correlation between PRO to each other but could not demonstrate a significant correlation between nasal airflow and quality of life in patients with CRSwNP. Also, we found a correlation between left and right nasal airflow, but not that biological treatment improves the nasal airflow and resistance in those under treatment. However, the updated guidelines recommend that the first evaluation should be done on week 24 instead of week 16.